TYMS
The TYMS gene encodes thymidylate synthase, a key enzyme involved in the synthesis of thymidine, one of the four nucleotides required for DNA replication and repair. This enzyme depends on active folate (5,10-methylene-THF) to function efficiently, linking TYMS closely to folate metabolism. Variants in the TYMS gene can affect folate availability at the cellular level and may influence how the body responds to folate or folate-based therapies. Such changes may contribute to impaired DNA synthesis, increased susceptibility to certain diseases, or varied responses to chemotherapy or supplementation.
Description
TYMS encodes thymidylate synthase, an enzyme essential for producing thymidine used in DNA synthesis and repair.
The enzyme uses active folate as a cofactor, so folate status significantly affects TYMS activity.
Certain variants may decrease enzyme efficiency, affecting DNA replication and folate utilisation.
Yes, they may influence susceptibility to disease or the effectiveness of folate-related therapies, including certain chemotherapy drugs.
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