Secondary bile acids
Secondary bile acids are formed in the colon through bacterial transformation of primary bile acids originally synthesised in the liver. While they play roles in digestion and microbial regulation, elevated levels may indicate dysbiosis, excessive fat intake, or altered bile acid metabolism. Some secondary bile acids, such as deoxycholic acid (DCA) and lithocholic acid (LCA), have been linked to mucosal irritation, inflammation, and an increased risk of colorectal disorders when persistently elevated. Measuring them in stool helps assess gut microbial activity and bile detoxification status.
Description
They are bile acids formed by intestinal bacteria from primary bile acids that originate in the liver.
To assess microbial activity, fat digestion, and potential mucosal effects associated with bile acid transformation.
It can indicate dysbiosis, high fat intake, or slowed intestinal transit, and may contribute to gut inflammation.
Not necessarily. In small amounts they help digestion, but consistently high levels may be irritating or promote inflammation.
Diet (particularly fat and fibre), microbial composition, and bile acid recycling efficiency all play a role.
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