MTHFS
The MTHFS gene encodes methenyltetrahydrofolate synthetase, an enzyme involved in folate metabolism. It plays a vital role in maintaining the pool of active folate derivatives used for methylation, DNA synthesis, and neurotransmitter production. MTHFS regulates the conversion of various folate forms and helps maintain the balance of one-carbon units essential for cellular function. Variants in this gene may disrupt folate recycling, potentially affecting methylation pathways and contributing to issues such as impaired detoxification, fatigue, or mood imbalance.
Description
MTHFS encodes an enzyme that helps regulate folate metabolism and supports methylation and nucleotide synthesis.
It ensures proper recycling and balance of folate derivatives necessary for effective methylation and DNA replication.
They may result in inefficient folate utilisation, contributing to elevated homocysteine levels, reduced detoxification capacity, or neurological symptoms.
They may be linked to tiredness, difficulty concentrating, mood disorders, or a sensitivity to folic acid supplements.
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